Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania

TE Van Rheenen; SM Cotton; O Dandash; RE Cooper; E Ringin; R Daglas-Georgiou; K Allott; Y Chye; C Suo; C Macneil; M Hasty; K Hallam; P McGorry; A Fornito; M Yücel; C Pantelis; M Berk

Journal article

Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania

TE Van Rheenen, SM Cotton, O Dandash, RE Cooper, E Ringin, R Daglas-Georgiou, K Allott, Y Chye, C Suo, C Macneil, M Hasty, K Hallam, P McGorry, A Fornito, M Yücel, C Pantelis, M Berk

Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2023

DOI: 10.1016/j.pnpbp.2022.110687

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Abstract

Background: Despite reports of altered brain morphology in established bipolar disorder (BD), there is limited understanding of when these morphological abnormalities emerge. Assessment of patients during the early course of illness can help to address this gap, but few studies have examined surface-based brain morphology in patients at this illness stage. Methods: We completed a secondary analysis of baseline data from a randomised control trial of BD individuals stabilised after their first episode of mania (FEM). The magnetic resonance imaging scans of n = 35 FEM patients and n = 29 age-matched healthy controls were analysed. Group differences in cortical thickness, surface area and gyrif..

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University of Melbourne Researchers

Tamsyn van Rheenen Author

Susan Cotton Author

Orwa Dandash Author

Elysha Ringin Author

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Awarded by AstraZeneca

Funding Acknowledgements

This trial was supported by an unrestricted grant from Astra Zeneca. Dr. Van Rheenen was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (1088785) and a Dame Kate Campbell Fellowship. Professor Pantelis was supported by an NHMRC Senior Principal Research Fellowship (628386 and 1105825) . Professor Berk was supported by a NHMRC Senior Principal Research Fellowship (1059660 and 1156072) . Associate Professor Allott was supported by a Career Development Fellowship from the NHMRC (1141207) . Professor Fornito was supported by the Sylvia and Charles Viertel Charitable Foundation. Professor Yucel received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #1117188) , the Australian Research Council (ARC) , Australian Defence Science and Technology (DST) , and the Department of Industry, Innovation and Science (DIIS) .